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. 2007 Aug 10;6:24. doi: 10.1186/1475-2859-6-24

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Copyright © 2007 Rasmussen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hairpin core sequence. Generalized representation of a minimal hairpin-substrate complex. N: any nucleotide, N': nucleotide complementary to N, H: any nucleotide but C, Y: pyrimidine nucleotide. Nucleotides in boldface indicate the conserved catalytic core nucleotides, and the arrow marks the cleavage site. Ribozyme numbering is according to Butcher and Burke [220, 221]. This representation displays in trans cleavage, but the catalytic core nucleotides and the cleavage site are the same for in cis cleavage.