Figure 3.

TH expression and dopamine levels in neural crest-derived cells of the newborn adrenal medulla. (A) In situ hybridization analysis of Nurr1 mRNA expression in the adrenal gland of a wild-type mouse. Nurr1 mRNA was detected in the medulla of the adrenal gland. (B) Dopamine levels in adrenal medulla of wild-type, heterozygous, and homozygous mice. No significant differences in dopamine levels were detected. TH immunoreactivity of wild-type (C) and mutant adrenal gland from newborn mice (D). (E and F) No detectable differences in TH immunoreactivity in the periglomerular dopaminergic cells of the olfactory bulb in wild-type and nurr1 null mutant mice, respectively. (Bar = 50 μm.)