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Mean pharmacokinetic parameters (mean ± SE) of LNG in women following a single intravaginal application of two different formulations of CARRA/LNG gels
| Pharmacokinetic parameters |
Dose of LNG |
|
|---|---|---|
| 0.75 mg/4 mL gel | 1.5 mg/4 mL gel | |
| Cmax (nmol/L) | 14.1 ± 2.1 | 11.7 ± 2.7 |
| Tmax (h) | 12.0 ± 2.7 | 6.0 ± 0.9 |
| AUC0-168 (nmol h/L) | 540 ± 105 | 352 ± 85 |
| Clearance (L/day) | 136 ± 31 | 505 ± 183 |
| Half life (h) | 34.0 ± 3.5 | 29.9 ± 3.0 |
