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Representative 5-day tracings of systolic and diastolic BP continuously recorded using a telemetric system. (a) An Npr1+/+ mouse and (b) an Npr1–/– mouse. Both mice have diurnal rhythms with about a 10 mmHg increase in BP during periods of darkness. Arrows indicate the addition of enalapril (0.12 g/l) to the drinking water. Enalapril decreases the BP in both Npr1+/+ and Npr1–/– mice.
