Figure 4.

Response of reconstituted follicles to anagen 7 weeks after implantation of cells. Mice were sacrificed 6 days after anagen initiation, 2 hours after BrdU injection. (a–d) BrdU incorporation (dark brown) assessed on paraffin sections. (e–h) AP activity (blue stain) and GFP expression (e and g, arrowheads). VDR status of cells implanted: (a and e) wild-type keratinocytes, wild-type dermal papilla cells; (b and f) VDR-null keratinocytes, wild-type dermal papilla cells; (c and g) wild-type keratinocytes, VDR-null dermal papilla cells; (d and h) VDR-null keratinocytes, VDR-null dermal papilla cells.