Table 1.
Aging and Longevity Phenotypes for Framingham Heart Study 100K Project
| Exam cycle(s) | |||||
|---|---|---|---|---|---|
|
Phenotype Subgroup • Trait (variable name on the website*) |
Number of Traits | N (MV**) | Offspring / Original Cohort | Adjustment | |
| Survival Traits: Cox regression | |||||
|
Survival • Age at death (1. deathageX, 2. deathageMV) |
2 | 1345 (1166) | Cohort & Offspring pooled | Cox regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, smoking, obesity (BMI ≥ 30), CVD risk factors, co-morbidity measured at exam 1 |
|
| Categorical traits: Logistic regression | |||||
| • Survival past the ALE (1. deathpastALEX, 2. deathpastALEMV) | 2 | 1345 (1166) | Cohort & Offspring pooled | Logistic regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, smoking, obesity (BMI ≥ 30), CVD risk factors, co-morbidity measured at exam 1 |
|
|
Morbidity-free survival (free of CVD, cancer and dementia) • At age 65 years (1. morbidityfree65X, 2. morbidityfree65MVX) |
2 | 558 (558) | Cohort & Offspring pooled, exams closest to age 65 years | Logistic regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, smoking, obesity, CVD risk factors measured at exam closest to age 65 years (within a 5 year horizon) |
|
| Quantitative Traits: Linear regression | |||||
|
Reproductive Aging • Age at natural menopause (1. menoageX, 2. menoageMVX) |
2 | 438 (378) | Cohort & Offspring pooled, women only | Linear regression 1. crude 2. multivariable adjusted for smoking, BMI, parity, generation (measured at exams prior to menopause) |
|
|
Cognitive function • MMSE at age 65 years (1. MMSE65X, 2. MMSE65MVX) • MMSE at the specified Offspring exam (1. MMSE5X, 2. MMSE5MVX, 1. MMSE7X, 2. MMSE7MV, 1. MMSE5to7X, 2. MMSE5to7MVX) |
2 | 593 (462) | Cohort & Offspring pooled, exams at age 65 | Linear regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, FSRP measured at exam closest to age 65 years (5 year horizon) |
|
| 6 | 1038 (913) | Exam 5 Exam 7 Exam 5 & 7 average score |
Linear regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, FSRP; covariates measured at the specified exam |
||
|
Physical Performance • Hand grip (2. handgrip7x, 2. handgrips727x) • Walking speed (2. walkingspeed7x, 2. walkingspeed727x) |
6 | 764 | Exam 7 Exam 7 and Exam 27 |
Linear regression Sex-specific‡ 1. age 2. multivariable adjusted for age, height, weight at the specified exam |
|
| Biologic Age by Osseographic Scoring System (1. deltaOSSr, delta OSSrf, deltaOSSrm) | 3 | 714 | Offspring and Cohort pooled exam 6/7 and exam 22 |
Linear regression Sex- and cohort-specific ranked residuals§ 1. multivariable adjusted for age, height, BMI, menopause, estrogen use |
|
Residuals from these models were used as traits to test for association with SNP genotypes.
* The number preceding the variable name refers to the covariate adjustment in the last column of the table. The website with all results is found at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007; ** MV = N for multivariable trait
‡ cohort- and sex-specific residuals for traits that included both cohort and offspring; §cohort-specific for traits limited to one sex
ALE = average life expectancy, BMI = body mass index, Co-morbidity = cardiovascular disease and cancer, CVD = cardiovascular disease, FSRP = Framingham stroke risk profile, MMSE = mini-mental state exam, Risk factors = hypertension, diabetes, elevated cholesterol