Table 3.
3a. FBAT: Age at Death and Morbidity-Free Survival at 65 years | |||||||||
---|---|---|---|---|---|---|---|---|---|
Trait 1 | Trait 2 | SNP | Chr | Physical Position | Gene | Trait 1 GEE p-value | Trait 1 FBAT p-value | Trait 2 GEE p-value | Trait 2 FBAT p-value |
Age at Death | Morbidity-free at 65 | rs6682403 | 1 | 234,743,324 | 0.849 | 0.004 | 0.106 | 0.004 | |
rs10488907 | 4 | 113,669,709 | ALPK1 | 0.452 | 0.008 | 0.336 | 0.009 | ||
rs17190837 | 9 | 13,391,548 | 0.010 | 0.009 | 0.097 | 0.004 | |||
rs4752977 | 11 | 47,257,005 | MADD | 0.736 | 0.008 | 0.002 | 0.009 | ||
rs10506274 | 12 | 80,103,932 | 0.531 | 0.001 | 0.989 | 0.001 | |||
rs2831154 | 21 | 28,059,331 | 0.323 | 0.008 | 0.358 | 0.006 | |||
rs243725* | 21 | 28,060,803 | 0.264 | 0.007 | 0.359 | 0.008 | |||
*r2 > 0.80 with the preceding SNP | |||||||||
3b. GEE: Age at Death and Morbidity-Free Survival at 65 years | |||||||||
Trait 1 | Trait 2 | SNP | Chr | Physical Position | Gene | Trait 1 GEE p-value | Trait 1 FBAT p-value | Trait 2 GEE p-value | Trait 2 FBAT p-value |
Age at Death | Morbidity-free at 65 | rs9308261 | 1 | 113,603,160 | MAGI3 | 0.009 | 0.156 | 0.002 | 0.900 |
rs10490518 | 2 | 31,223,004 | GALNT14 | 0.009 | 0.373 | 0.010 | 0.948 | ||
rs2374983 | 7 | 94,516,375 | PPP1R9A/PON1 | 0.006 | 0.980 | 0.007 | 0.727 | ||
rs655883 | 11 | 98,994,584 | CNTN5 | 0.006 | 0.390 | 0.001 | 0.293 | ||
rs1368850 | 11 | 130,433,518 | 0.004 | 0.387 | 0.005 | 0.292 | |||
rs4943116 | 13 | 32,995,650 | STARD13 | 0.006 | 0.205 | 0.008 | 0.049 | ||
rs2254191 | 13 | 45,344,403 | 0.007 | 0.425 | 0.004 | 0.116 | |||
rs1620210 | 13 | 45,759,488 | C13orf18 | 0.001 | 0.161 | 0.004 | 0.068 | ||
rs2823322 | 21 | 15,814,903 | 0.0004 | 0.045 | 0.006 | 0.029 | |||
3c. FBAT: Biologic Age and Walking Speed | |||||||||
Trait 1 | Trait 2 | SNP | Chr | Physical Position | Gene | Trait 1 GEE p-value | Trait 1 FBAT p-value | Trait 2 GEE p-value | Trait 2 FBAT p-value |
Biologic age | Walking speed | rs873348 | 4 | 178,246,509 | 0.135 | 0.004 | 0.114 | 0.006 | |
Biologic age | Walking speed | rs10520361* | 4 | 178,247,037 | 0.074 | 0.006 | 0.054 | 0.005 | |
Biologic age | Walking speed | rs31564 | 5 | 135,258,152 | IL9 | 0.015 | 0.001 | 0.008 | 0.002 |
Biologic age | Walking speed | rs1862345 | 5 | 148,018,498 | HTR4 | 0.172 | 0.0002 | 0.399 | 0.008 |
Biologic age | Walking speed | rs7844834 | 8 | 11,323,556 | C8orf12|C8orf13 | 0.017 | 0.004 | 0.011 | 0.004 |
Biologic age | Walking speed | rs952658 | 12 | 20,756,568 | SLCO1C1 | 0.024 | 0.008 | 0.935 | 0.006 |
Biologic age | Walking speed | rs6487366 | 12 | 23,994,617 | SOX5 | 0.017 | 0.003 | 0.959 | 0.004 |
Biologic age | Walking speed | rs7135493 | 12 | 28,134,847 | 0.020 | 0.006 | 0.033 | 0.004 | |
Biologic age | Walking speed | rs10492036 | 12 | 124,728,934 | 0.308 | 0.005 | 0.169 | 0.009 | |
Biologic age | Walking speed | rs1978945 | 13 | 105,641,257 | 0.093 | 0.009 | 0.031 | 0.006 | |
Biologic age | Walking speed | rs2165723* | 13 | 105,641,610 | 0.046 | 0.010 | 0.027 | 0.003 | |
Biologic age | Walking speed | rs10492651* | 13 | 105,641,634 | 0.083 | 0.009 | 0.023 | 0.001 | |
Biologic age | Walking speed | rs9301112* | 13 | 105,642,018 | 0.097 | 0.004 | 0.053 | 0.003 | |
* r2 > 0.8 with the preceding SNP (calculated if the distance is <250,000 base pairs) | |||||||||
3d. GEE: Biologic Age and Walking Speed | |||||||||
Trait 1 | Trait 2 | SNP | Chr | Physical Position | Gene | Trait 1 GEE p-value | Trait 1 FBAT p-value | Trait 2 GEE p-value | Trait 2 FBAT p-value |
Biologic Age | Walking speed | rs1474827 | 6 | 134,886,011 | 0.007 | 0.746 | 0.000 | 0.233 | |
Biologic Age | Walking speed | rs10231641 | 7 | 119,166,342 | 0.004 | 0.077 | 0.009 | 0.278 | |
Biologic Age | Walking speed | rs310575 | 8 | 51,603,257 | SNTG1 | 0.008 | 0.209 | 0.003 | 0.007 |
Biologic Age | Walking speed | rs10520603 | 15 | 84,170,955 | 0.009 | 0.008 | 0.003 | 0.050 | |
Biologic Age | Walking speed | rs7166323* | 15 | 84,171,745 | 0.009 | 0.012 | 0.003 | 0.065 | |
Biologic Age | Walking speed | rs2215921 | 16 | 9,604,834 | 0.007 | 0.049 | 0.001 | 0.316 | |
* r2 > 0.8 with the preceding SNP (calculated if the distance is <250,000 base pairs) | |||||||||