Table 1.

Phenotype definitions

Phenotype	Definition	Number of individuals	Number with event	Adjustment*
Major CVD	Myocardial infarction, coronary insufficiency, CHD death, or atherothrombotic stroke	1345	142	Age, sex; Multivariable: Age, sex, smoking, diabetes, systolic BP, anti-hypertensive therapy, total cholesterol
Major CHD	Myocardial infarction, coronary insufficiency, or CHD death	1345	118	Same as Major CVD
Heart failure	Heart failure, hospitalized or non-hospitalized	1345	73	Same as Major CVD except BMI added, total cholesterol removed
Atrial fibrillation	Atrial fibrillation or atrial flutter on ECG	1341	151	Age, sex; Multivariable: Age, sex, diabetes, systolic BP, anti-hypertensive therapy, valve disease

* Covariates in cohort-stratified proportional-hazards models for time to event