Table 4.
Association Results for Pre-Specified Candidate Genes
| Candidate gene | Total number of SNPs* | SNPs with p value < 0.05 | Phenotype | GEE p value | FBAT p value |
|---|---|---|---|---|---|
| Major CVD/Major CHD | |||||
| ALOX5 | 5 | 0 | |||
| ALOX5AP | 23 | rs7983138 | Major CHD | 0.011 | 0.373 |
| rs2985183 | Major CHD | 0.014 | 0.455 | ||
| rs7984952 | Major CHD | 0.015 | 0.266 | ||
| rs117395 | Major CHD | 0.016 | 0.568 | ||
| rs4603405 | Major CHD | 0.018 | 0.257 | ||
| rs10507391 | Major CHD | 0.028 | 0.660 | ||
| rs10507391 | Major CVD | 0.043 | 0.878 | ||
| rs7995384 | Major CHD | 0.049 | 0.967 | ||
| GJA4 | 14 | rs618675 | Major CHD | 0.004 | 0.169 |
| rs10489658 | Major CHD | 0.004 | 0.145 | ||
| rs618675 | Major CVD | 0.009 | 0.464 | ||
| rs10493062 | Major CHD | 0.011 | 0.051 | ||
| rs768586 | Major CHD | 0.016 | 0.135 | ||
| rs10489658 | Major CVD | 0.025 | 0.237 | ||
| rs10489656 | Major CHD | 0.520 | 0.030 | ||
| rs10489656 | Major CVD | 0.538 | 0.044 | ||
| rs2093185 | Major CVD | 0.547 | 0.019 | ||
| rs6686484 | Major CHD | 1.000 | 0.031 | ||
| LGALS2 | 1 | 0 | |||
| LTA | 2 | 0 | |||
| LTA4H | 22 | rs10492225 | Major CHD | 0.013 | 0.080 |
| MEF2A | 5 | rs2033546 | Major CVD | 0.004 | 0.006 |
| rs2863274 | Major CVD | 0.006 | 0.006 | ||
| rs2033546 | Major CHD | 0.016 | 0.013 | ||
| rs2863274 | Major CHD | 0.062 | 0.021 | ||
| MMP3 | 17 | rs2096767 | Major CVD | 0.028 | 0.506 |
| rs2096767 | Major CHD | 0.032 | 0.610 | ||
| rs566125 | Major CVD | 0.042 | 0.079 | ||
| SERPINE1 | 2 | 0 | |||
| PCSK9 | 11 | rs2114580 | Major CHD | 0.010 | 0.075 |
| rs2114580 | Major CVD | 0.026 | 0.057 | ||
| rs2317951 | Major CVD | 0.076 | 0.002 | ||
| rs2317951 | Major CHD | 0.077 | 0.002 | ||
| rs2317948 | Major CHD | 0.478 | 0.029 | ||
| rs2317948 | Major CVD | 0.584 | 0.026 | ||
| THBS2 | 7 | rs911839 | Major CVD | 0.192 | 0.035 |
| rs911839 | Major CHD | 0.255 | 0.032 | ||
| THBS4 | 16 | rs264986 | Major CHD | 0.443 | 0.048 |
| VAMP8 | 5 | 0 | |||
| Atrial fibrillation | |||||
| ACE | 3 | 0 | |||
| AGT | 13 | rs758216 | 0.041 | 0.204 | |
| GJA5 | 13 | 0 | |||
| KCNE2 | 14 | 0 | |||
| KCNH2 | 6 | 0 | |||
| KCNJ2 | 23 | rs10512574 | 0.140 | 0.041 | |
| KCNQ1 | 5 | rs10488674 | 0.136 | 0.046 | |
| KCNE1 | 20 | rs7277304 | 0.745 | 0.047 | |
| rs9305551 | 0.119 | 0.018 | |||
| Heart failure | |||||
| ABCC9 | 8 | 0 | |||
| ACTC | 15 | rs752876 | 0.065 | 0.040 | |
| ADRB1 | 12 | 0 | |||
| ADRB2 | 18 | rs40949 | 0.545 | 0.025 | |
| rs185021 | 0.947 | 0.040 | |||
| ADRBK1 | 0 | - | |||
| ATP2A2 | 3 | 0 | |||
| CALML3 | 2 | 0 | |||
| CTF1 | 0 | - | |||
| DES | 2 | 0 | |||
| DSP | 15 | rs10484326 | 0.671 | 0.029 | |
| LDB3 | 0 | - | |||
| LMNA | 5 | 0 | |||
| MYBPC3 | 4 | 0 | |||
| MYH6 | 1 | 0 | |||
| MYH7 | 2 | 0 | |||
| MYL2 | 3 | 0 | |||
| MYL3 | 1 | 0 | |||
| PLN | 16 | rs3951042 | 0.025 | 0.083 | |
| rs724868 | 0.055 | 0.039 | |||
| rs9320660 | 0.063 | 0.034 | |||
| rs10484286 | 0.074 | 0.043 | |||
| SGCD | 37 | 0 | |||
| TNNC1 | 4 | rs1133415 | 0.040 | 0.131 | |
| TNNI3 | 1 | 0 | |||
| TNNT2 | 9 | rs832177 | 0.015 | 0.164 | |
| TPM1 | 7 | rs10519186 | 0.011 | 0.085 | |
| rs902027 | 0.152 | 0.011 | |||
| TTN | 13 | rs10497521 | 0.705 | 0.030 | |
| VCL | 3 | 0 | |||
*Includes all SNPs within 200 kb upstream of start to 200 kb downstream of end of gene, with genotype call rate ≥0.8; minor allele frequency ≥0.1; HWE p ≥ 0.001.
Data are sorted by GEE additive genetic effects model with FBAT results provided alongside.