Table 1.
Traits names, Framingham Heart Study examination cycle, and multivariable adjustments
| Trait | Sample size | Exam cycle/s | ||
|---|---|---|---|---|
| Offspring | Original Cohort | Adjustment† | ||
| Serum Creatinine | 840–1010 | 2, 5, 6, 7 | 0 | Age and sex; multivariable* |
| Change in serum creatinine | 854 | 2, 7 | 0 | Age and sex; multivariable* |
| Glomerular Filtration Rate (GFR) | 840–1010 | 2, 5, 6, 7 | 0 | Age and sex; multivariable* |
| Chronic Kidney Disease | 1010 | 7 | 0 | Age and sex; multivariable* |
| Cystatin C | 981 | 7 | 0 | Age and sex; multivariable* |
| Uric acid | 912–1031 | 1, 2 | 0 | Age and sex; multivariable* |
| Urinary Albumin Excretion | 822 | 6 | 0 | Age and sex; multivariable* |
| Urinary Albumin Excretion ≥ 30 mg/g; Hypertension-enriched sample | 532 | 6 | 0 | Age and sex; multivariable* |
| Serum Calcium | 906 | 2 | 0 | Age and sex; age, sex, serum creatinine |
| Serum Phosphorus | 911 | 2 | 0 | Age and sex; age, sex, and serum creatinine |
| Thyroid stimulation hormone (TSH) | 883 | 3 | 0 | Age and sex; age, sex, body mass index, smoking, menopausal status, thyroid hormone use |
| Mean of TSH exam 3 & 4 | 810 | 3, 4 | 0 | Age and sex; age, sex, body mass index, smoking, menopausal status, thyroid hormone use |
| Luteinizing hormone (LH) ** | 508 | 3 | 0 | Age and multivariable*** |
| Follicle stimulating hormone (FSH)** | 509 | 3 | 0 | Age and multivariable*** |
| Dehydroepiandrosterone sulfate (DHEAS) | 850 | 3 | 0 | Age and sex; multivariable*** |
*Multivariable adjustment include age, sex, systolic blood pressure, hypertension treatment, HDL-cholesterol, smoking, diabetes, body mass index
**Men and post-menopausal women only with natural menopause not using hormone replacement treatment or oral contraceptive pills
*** Age, diabetes mellitus, impaired fasting glucose, smoking, systolic blood pressure, diastolic blood pressure, body-mass index, hypertension treatment, prevalent cardiovascular disease, total cholesterol/HDL ratio and alcohol intake