Table 3.
Top GEE association results for electrocardiographic phenotypes
| Trait | SNP rank | rs ID | Chromosome | Physical Position | GEE p-value | FBAT p-value | Gene region (within 60 kb) |
|---|---|---|---|---|---|---|---|
| Top 8 QT interval SNPs | |||||||
| QT | 1 | rs10507380 | 13 | 26777526 | 8.4 × 10-6 | 0.665 | RPL21 |
| QT | 2 | rs2726920 | 11 | 108252434 | 4.2 × 10-5 | 0.865 | DDX10 |
| QT | 3 | rs763552 | 8 | 31564949 | 4.7 × 10-5 | 0.033 | NRG1 |
| QT | 4 | rs366307 | 5 | 150527337 | 4.9 × 10-5 | 0.104 | ANXA6 |
| QT | 5 | rs3858646 | 12 | 114038413 | 7.7 × 10-5 | 1.3 × 10-4 | |
| QT | 6 | rs1558139 | 19 | 15858564 | 8.2 × 10-5 | 6.0 × 10-5 | CYP4F2 |
| QT | 7 | rs1695508 | 7 | 28739796 | 8.5 × 10-5 | 0.002 | |
| QT | 8 | rs10495588 | 2 | 12153871 | 8.7 × 10-5 | 0.001 | |
| Top 8 RR interval SNPs | |||||||
| RR | 1 | rs2179896 | 14 | 53945264 | 1.7 × 10-5 | 0.032 | |
| RR | 2 | rs10518674 | 15 | 50105438 | 1.9 × 10-5 | 0.033 | MAPK6 |
| RR | 3 | rs321967 | 7 | 77959200 | 2.6 × 10-5 | 0.018 | MAGI2 |
| RR | 4 | rs4319121 | 8 | 53668308 | 3.6 × 10-5 | 0.571 | |
| RR | 5 | rs844429 | 10 | 80016392 | 4.5 × 10-5 | 0.032 | |
| RR | 6 | rs4345013 | 22 | 25706391 | 4.9 × 10-5 | 0.227 | |
| RR | 7 | rs2643191 | 3 | 165861395 | 5.2 × 10-5 | 2.5 × 10-4 | |
| RR | 8 | rs2932529 | 1 | 112905406 | 5.7 × 10-5 | 0.232 | CAPZA1 |
| Top 8 PR interval SNPs | |||||||
| PR | 1 | rs882300 | 2 | 136809987 | 3.2 × 10-7 | 0.133 | |
| PR | 2 | rs10518795 | 15 | 53131579 | 1.1 × 10-5 | 0.062 | |
| PR | 3 | rs7201988 | 16 | 9516007 | 3.0 × 10-5 | 0.001 | |
| PR | 4 | rs2096767 | 11 | 102296609 | 3.1 × 10-5 | 0.031 | MMP13 |
| PR | 5 | rs2831936 | 21 | 28922444 | 3.1 × 10-5 | 0.011 | |
| PR | 6 | rs10516736 | 4 | 82325666 | 5.1 × 10-5 | 0.014 | BMP3 |
| PR | 7 | rs4488182 | 11 | 41032137 | 5.4 × 10-5 | 0.008 | |
| PR | 8 | rs10489798 | 1 | 96957067 | 6.2 × 10-5 | 0.086 | PTBP2 |
| Top 8 LF/HF SNPs | |||||||
| LF/HF | 1 | rs1395479 | 4 | 178693340 | 6.9 × 10-6 | 0.034 | NEIL3 |
| LF/HF | 2 | rs2215456 | 12 | 40596176 | 1.3 × 10-5 | 0.002 | |
| LF/HF | 3 | rs1336938 | 13 | 88369006 | 1.6 × 10-5 | 0.003 | |
| LF/HF | 4 | rs796184 | 13 | 88515431 | 1.9 × 10-5 | 0.003 | |
| LF/HF | 5 | rs4669749 | 2 | 11643262 | 2.0 × 10-5 | 0.113 | GREB1 |
| LF/HF | 6 | rs1871841 | 8 | 13674417 | 2.1 × 10-5 | 0.015 | |
| LF/HF | 7 | rs721691 | 7 | 128485610 | 3.0 × 10-5 | 0.026 | |
| LF/HF | 8 | rs10509700 | 10 | 97884521 | 4.2 × 10-5 | 0.864 | |
| Top 8 Total Power SNPs | |||||||
| TP | 1 | rs9315385 | 13 | 35561302 | 7.7 × 10-6 | 0.031 | DCAMKL1 |
| TP | 2 | rs2276886 | 4 | 77285607 | 1.5 × 10-5 | 0.004 | CXCL9 |
| TP | 3 | rs726698 | 2 | 35366992 | 2.2 × 10-5 | 0.001 | |
| TP | 4 | rs1330948 | 13 | 106192232 | 2.4 × 10-5 | 0.016 | |
| TP | 5 | rs2283064 | 7 | 125719004 | 3.0 × 10-5 | 0.042 | GRM8 |
| TP | 6 | rs10515199 | 5 | 74135390 | 3.8 × 10-5 | 0.113 | |
| TP | 7 | rs1407709 | 1 | 184794336 | 4.0 × 10-5 | 0.042 | |
| TP | 8 | rs1723482 | 2 | 47318190 | 5.5 × 10-5 | 0.040 | |
| Top 8 SDNN SNPs | |||||||
| SDNN | 1 | rs2966762 | 5 | 109411118 | 2.0 × 10-5 | 0.024 | |
| SDNN | 2 | rs286751 | 5 | 107430837 | 2.1 × 10-5 | 4.1 × 10-5 | FBXL17 |
| SDNN | 3 | rs1013621 | 8 | 52963944 | 4.0 × 10-5 | 0.018 | |
| SDNN | 4 | rs1378506 | 5 | 109419129 | 4.5 × 10-5 | 0.110 | |
| SDNN | 5 | rs1866559 | 2 | 27247237 | 5.3 × 10-5 | 0.405 | CGREF1 |
| SDNN | 6 | rs2049161 | 18 | 4117583 | 5.9 × 10-5 | 0.036 | |
| SDNN | 7 | rs9297393 | 8 | 108356753 | 6.4 × 10-5 | 0.587 | ANGPT1 |
| SDNN | 8 | rs7012655 | 8 | 52740967 | 8.4 × 10-5 | 0.007 | |
The top 8 association results for ECG phenotypes QT, RR and PR interval and for HRV phenotypes low frequency to high frequency power (LF/HF), total power (TP) and standard deviation of normal RR intervals (SDNN) are shown from a total 70,987 SNPs tested in additive genetic models using GEE. Chromosome and physical position using NCBI build 35 reference sequence (hg17) are shown. The corresponding FBAT p-value is shown (note: the number of informative families varies substantially). Genes within 60 kb of a SNP are shown.