Table 4.
Suggestive linkage results for ECG and HRV phenotypes
| phenotype | maximum LOD | SNP | chromosome | position (Mb) | 1.5 LOD CI |
|---|---|---|---|---|---|
| ECG | |||||
| PR | 2.98 | rs1011725 | 4 | 124.75 | 113.07 – 138.58 |
| QT | 2.52 | rs10512617 | 17 | 74.21 | 66.43 – 76.22 |
| QT | 2.50 | rs164462 | 3 | 8.72 | 5.49 – 13.81 |
| HRV | |||||
| LF/HF | 2.39 | rs10519165 | 15 | 75.51 | 67.57 – 79.33 |
| TP | 2.19 | rs10500600 | 11 | 4.40 | 0.80 – 11.77 |
Shown are the linkage results exceeding a maximum multipoint LOD score of 2.0 for electrocardiographic QT, RR and PR intervals and the ratio of low frequency to high frequency power, total power and the standard deviation of normal RR intervals. The SNP at the maximum LOD score is shown as well as the confidence interval spanning the 1.5 LOD drop from the maximum.
Mb = megabase; CI = confidence interval; ECG = electrocardiogram; PR = PR interval adjusted for age, sex, RR interval; QT = QT interval adjusted for age, sex, RR interval; HRV = heart rate variability; LF/HF = ratio of low frequency to high frequency power; TP = total power.