Table 5.
Associations achieving nominal genome wide significance, p < 5*10-8 across the 17 phenotype working groups
| Phenotype working group/manuscript | Trait | SNP rs ID* | Chr | Physical location (bp) | GEE P-value | FBAT P-value | IN/NEAR gene |
|---|---|---|---|---|---|---|---|
| Select biomarkers [33] | Monocyte chemoattractant protein-1 | rs2494250 | 1 | 156,091,324 | 1.0*10-14 | 3.5*10-8 | FCER1A, OR10J3 |
| Monocyte chemoattractant protein-1 | rs4128725 | 1 | 156,219,032 | 3.7*10-12 | 3.3*10-8 | OR10J1 | |
| C-reactive protein average exams 2,6,7 | rs2794520 | 1 | 156,491,889 | 2.8*10-8 | 4.3*10-5 | CRP | |
| C-reactive protein average exams 2,6,7 | rs2808629 | 1 | 156,489,869 | 3.2*10-8 | 4.8*10-5 | CRP | |
| Kidney/Endocrine [42] | Cystatin C | rs1158167 | 20 | 23,526,189 | 8.5*10-09 | 0.006 | CST9L|CST9|CST3 |
| Diabetes [38] | 28-year mean fasting plasma glucose | rs2722425 | 8 | 40,603,396 | 2.0*10-8 | 0.005 | ZMAT4 |
| Sleep and circadian [26] | Epworth sleepiness scale | rs1823068 | 5 | 58,711,806 | 2.5*10-8 | 0.069 | PDE4D |
| Neurology [37] | Total Cerebral Brain Volume (ATCBV) | rs1970546 | 20 | 59287333 | 4.0*10-8 | 0.005 | CDH4 |
| Hemostatic factors [34] | Factor VII | rs561241 | 13 | 112,808,035 | 4.5*10-16 | 3.4*10-4 | F7 |
The following phenotype working groups did not have any traits achieving nominal genome-wide significance: echocardiography, flow-mediated dilation and exercise tolerance testing; blood pressure and tonometry; subclinical cardiovascular disease; cardiovascular outcomes; cancer; electrocardiography and heart rate variability; pulmonary function testing; aging; bone; lipids; obesity