Table 3.
The 25 SNPs with lowest GEE association tests p-values with hematological phenotypes
| Phenotype* | SNP | MAF | CHR | Physical Position (bp)† | GEE Pval (Rank)†† | FBAT Pval††† | Genes within 60 Kb |
|---|---|---|---|---|---|---|---|
| Hgb | rs4133289 | 0.19 | 1 | 156,267,010 | 1.6 × 10-7(2) | 6.0 × 10-4 | OR10J1; OR10J5 |
| Hgb | rs1510107 | 0.41 | 2 | 53,071,788 | 1.0 × 10-5(17) | 2.2 × 10-3 | |
| Hgb | rs1160297 | 0.43 | 2 | 53,148,971 | 1.0 × 10-6(4) | 8.3 × 10-4 | |
| Hgb | rs2357013 | 0.45 | 2 | 53,177,780 | 6.1 × 10-6(14) | 1.3 × 10-3 | |
| Hgb | rs7844723 | 0.45 | 8 | 122,977,684 | 2.1 × 10-6(5) | 2.6 × 10-3 | |
| MCH | rs1829883 | 0.41 | 5 | 98,809,002 | 5.8 × 10-6(11) | 1.4 × 10-2 | |
| MCH | rs1200821 | 0.47 | 10 | 37,599,586 | 5.9 × 10-6(13) | 1.0 × 10-1 | ANKRD30A |
| MCH | rs1397048 | 0.40 | 11 | 56,222,675 | 6.9 × 10-8(1) | 1.0 × 10-2 | OR5AP2; OR5AR1; OR9G1; OR9G4 |
| platelet aggregation (ADP-induced) | rs10493895 | 0.19 | 1 | 97,983,247 | 1.6 × 10-5(23) | 4.5 × 10-2 | BC064027; DPYD |
| platelet aggregation (ADP-induced) | rs10484128 | 0.15 | 14 | 97,712,325 | 5.8 × 10-6(12) | 1.3 × 10-3 | |
| platelet aggregation (collagen-induced) | rs848523 | 0.42 | 2 | 36,659,307 | 2.1 × 10-5(24) | 4.3 × 10-1 | CRIM1 |
| platelet aggregation (collagen-induced) | rs565229 | 0.10 | 11 | 121,694,675 | 3.7 × 10-6(6) | 2.6 × 10-2 | |
| platelet aggregation (collagen-induced) | rs10506458 | 0.13 | 12 | 61,731,359 | 4.5 × 10-6(9) | 1.1 × 10-4 | |
| platelet aggregation (Epi-induced) | rs6811964 | 0.11 | 4 | 158,143,059 | 1.3 × 10-5(20) | 5.5 × 10-2 | PDGFC |
| platelet aggregation (Epi-induced) | rs1958208 | 0.32 | 14 | 81,194,793 | 1.1 × 10-5(18) | 7.0 × 10-1 | |
| platelet aggregation (Epi-induced) | rs10502583 | 0.17 | 18 | 28,011,131 | 1.1 × 10-5(19) | 1.1 × 10-2 | RNF138; MEP1B |
| RBCC | rs9253 | 0.18 | 1 | 37,627,906 | 4.2 × 10-6(7) | 1.1 × 10-5 | FLJ11730; BC016328 |
| RBCC | rs10489087 | 0.13 | 4 | 13,470,685 | 4.5 × 10-6(8) | 9.6 × 10-4 | |
| RBCC | rs636864 | 0.21 | 6 | 149,567,299 | 6.3 × 10-6(15) | 1.3 × 10-4 | |
| RBCC | rs727979 | 0.14 | 6 | 149,635,613 | 7.5 × 10-6(16) | 2.6 × 10-5 | MAP3K7IP2 |
| RBCC | rs6108011 | 0.28 | 20 | 7,500,504 | 5.8 × 10-6(10) | 7.0 × 10-2 | |
| Viscosity | rs10490258 | 0.11 | 2 | 40,717,605 | 1.5 × 10-5(21) | 2.9 × 10-2 | |
| Viscosity | rs1359339 | 0.18 | 6 | 18,606,507 | 2.2 × 10-5(25) | 2.3 × 10-2 | IBRDC2 |
| Viscosity | rs10485968 | 0.20 | 7 | 81,108,037 | 1.6 × 10-5(22) | 3.0 × 10-3 | |
| Viscosity | rs7159841 | 0.21 | 14 | 46,933,585 | 2.1 × 10-7(3) | 2.0 × 10-1 | MAMDC1 |
* For Hgb, MCH and RBCC reported here, multivariable adjusted residuals from average of measurements over exam cycles 1 and 2 were used; for all platelet aggregation phenotypes, and viscosity reported here, multivariable adjusted residuals from measurements at examination cycle 5 were used.
†Physical position is in base pair (bp) and based on the May 2004 human reference sequence (NCBI Build 35).
††P-value from GEE genotype association test and rank of the GEE p-values in ascending order.
†††P-value from family-based association test using the FBAT program.