Table 5.
Top 10 ranked SNPs in combining GEE association tests of ADP-induced, Collagen-induced and Epi-induced platelet aggregation levels
| GEE P-value of individual phenotypes | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | MAF | CHR | Physical Position (bp)* | Mean GEE p-value | Range of Beta Coefficient† (min, max) | Number of Phenotypes with GEE P-value < 0.01 | Gene within 60 Kb | ADP | Collagen | Epi | |
| rs10500631 | 0.13 | 11 | 4,882,639 | 6.6 × 10-3 | 0.19 | 0.24 | 3 | OR51S1; OR51T1; OR51A7; OR51G2; OR51G1; OR51A4; OR51A2 | 9.7 × 10-3 | 7.8 × 10-3 | 3.8 × 10-3 |
| rs930323 | 0.18 | 1 | 221,172,525 | 1.9 × 10-3 | -0.26 | -0.16 | 2 | CNIH3 | 3.8 × 10-2 | 1.6 × 10-3 | 1.2 × 10-4 |
| rs7033457 | 0.25 | 9 | 7,383,934 | 2.6 × 10-3 | 0.15 | 0.24 | 2 | 2.5 × 10-3 | 3.7 × 10-2 | 2.0 × 10-4 | |
| rs2974490 | 0.11 | 5 | 113,433,775 | 2.7 × 10-3 | 0.07 | 0.28 | 2 | 4.2 × 10-1 | 8.7 × 10-5 | 5.2 × 10-4 | |
| rs10517543 | 0.13 | 4 | 40,332,115 | 3.2 × 10-3 | 0.13 | 0.27 | 2 | AF262323; FLJ20273 | 5.8 × 10-3 | 1.0 × 10-1 | 5.2 × 10-5 |
| rs2916601 | 0.13 | 5 | 89,556,637 | 3.5 × 10-3 | 0.11 | 0.29 | 2 | 9.7 × 10-2 | 3.2 × 10-4 | 1.4 × 10-3 | |
| rs4350297 | 0.18 | 10 | 106,463,038 | 3.9 × 10-3 | -0.24 | -0.10 | 2 | SORCS3 | 3.5 × 10-4 | 1.0 × 10-1 | 1.7 × 10-3 |
| rs7956194 | 0.42 | 12 | 108,340,545 | 4.3 × 10-3 | 0.09 | 0.20 | 2 | FLJ37587; KCTD10; BC040062; AK056912; BC051266; UBE3B | 3.6 × 10-3 | 1.1 × 10-1 | 2.0 × 10-4 |
* Physical position is in base pair (bp) and based on the May 2004 human reference sequence (NCBI Build 35).
†β coefficient is the change in the phenotype in one standardized deviation unit with an increment of a copy of the alphabetically higher allele.