Table 1.
Phenotype List
| Exam cycle/s | |||||
|---|---|---|---|---|---|
| N* | Offspring | Cohort | Adjustment | Covariates | |
| Primary Phenotypes | |||||
| Blood Pressure | |||||
| SBP 1 | 2 | 1 | 12 | Age and sex, multivariable | Cohort, sex, age, BMI |
| SBP 7 | 2 | 7 | 26 | Age and sex, multivariable | Cohort, sex, age, BMI |
| SBP 1–7 | 2 | Mean of exams 1–7 | Mean of exams 12, 16, 18, 20, 22, 24, 26 | Age and sex, multivariable | Cohort, sex, age, BMI |
| DBP 1 | 2 | 1 | 12 | Age and sex, multivariable | Cohort, sex, age, BMI |
| DBP 7 | 2 | 7 | 26 | Age and sex, multivariable | Cohort, sex, age, BMI |
| DBP 1–7 | 2 | Mean of exams 1–7 | Mean of exams 12, 16, 18, 20, 22, 24, 26 | Age and sex, multivariable | Cohort, sex, age, BMI |
| Tonometry | |||||
| Carotid-femoral PWV | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| Carotid-brachial PWV | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| Forward pressure wave | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| Reflected pressure wave | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| Mean arterial pressure | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| Secondary Phenotypes^ | |||||
| Blood Pressure | |||||
| DBP 2 | 2 | 2 | 16 | Age and sex, multivariable | Cohort, sex, age, BMI |
| DBP 3 | 2 | 3 | 18 | Age and sex, multivariable | Cohort, sex, age, BMI |
| DBP 4 | 2 | 4 | 20 | Age and sex, multivariable | Cohort, sex, age, BMI |
| DBP 5 | 2 | 5 | 22 | Age and sex, multivariable | Cohort, sex, age, BMI |
| DBP 6 | 2 | 6 | 24 | Age and sex, multivariable | Cohort, sex, age, BMI |
| SBP 2 | 2 | 2 | 16 | Age and sex, multivariable | Cohort, sex, age, BMI |
| SBP 3 | 2 | 3 | 18 | Age and sex, multivariable | Cohort, sex, age, BMI |
| SBP4 | 2 | 4 | 20 | Age and sex, multivariable | Cohort, sex, age, BMI |
| SBP 5 | 2 | 5 | 22 | Age and sex, multivariable | Cohort, sex, age, BMI |
| SBP 6 | 2 | 6 | 24 | Age and sex, multivariable | Cohort, sex, age, BMI |
| PP 1 | 2 | 1 | 12 | Age and sex, multivariable | Cohort, sex, age, BMI |
| PP 2 | 2 | 2 | 16 | Age and sex, multivariable | Cohort, sex, age, BMI |
| PP 3 | 2 | 3 | 18 | Age and sex, multivariable | Cohort, sex, age, BMI |
| PP 4 | 2 | 4 | 20 | Age and sex, multivariable | Cohort, sex, age, BMI |
| PP 5 | 2 | 5 | 22 | Age and sex, multivariable | Cohort, sex, age, BMI |
| PP 6 | 2 | 6 | 24 | Age and sex, multivariable | Cohort, sex, age, BMI |
| PP 7 | 2 | 7 | 26 | Age and sex, multivariable | Cohort, sex, age, BMI |
| PP 1–7 | 2 | Mean of exams 1–7 | Mean of exams 12, 16, 18, 20, 22, 24, 26 | Age and sex, multivariable | Cohort, sex, age, BMI |
| Tonometry | |||||
| 1/CF-PWV | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| AI | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| CPP | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| CR-PWV | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| DBP-osc | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| PA-1 | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| PA-2 | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| PP-osc | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| RWTT | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
| SBP-osc | 2 | 7 | Not included | Age and sex, multivariable | Sex, age, age^2, height, weight |
*n = number of phenotypes analyzed
^Association results for primary and secondary phenotypes are available on the worldwide web at: http://web.ncbi.nlm.nih.gov/projects/gap/framingham/cgi-bin/study.cgi?id=phs000007
AI = augmentation index; CPP = central pulse pressure; CB-PWV = carotid brachial pulse wave velocity; CF-PWV = carotid-femoral pulse wave velocity; CR-PWV = carotid-radial pulse wave velocity; DBP = diastolic blood pressure; DBP-osc = brachial DBP by oscillometric device; FW = forward wave amplitude; MAP = mean arterial pressure; PA-1 = apparent peripheral amplification; PA-2 = true peripheral amplification; PP = pulse pressure; PP-osc = brachial PP by oscillometric device; RW = reflected wave amplitude; RWTT = reflected wave transit time; SBP = systolic blood pressure; SBP-osc = brachial SBP by oscillometric device; 1/CF-PWV = inverse of CF-PWV.