Table 5.
Results for Pre-Specified Candidate Genes
| Candidate gene | Total number of SNPs* | SNPs with p value < 0.05 | Phenotype | GEE p value | FBAT p value |
|---|---|---|---|---|---|
| Diastolic blood pressure | |||||
| ACE | 3 | 0 | |||
| AGT | 13 | rs2478518 | 0.021 | 0.186 | |
| AGTR1 | 17 | 0 | |||
| CYP11B2 | 1 | 0 | |||
| NR3C2 | 26 | rs6845733 | 0.008 | 0.399 | |
| REN | 9 | 0 | |||
| Systolic blood pressure | |||||
| ACE | 3 | 0 | |||
| AGT | 13 | rs2478518 | 0.003 | 0.275 | |
| AGTR1 | 17 | 0 | |||
| CYP11B2 | 1 | 0 | |||
| NR3C2 | 26 | rs6845733 | 0.010 | 0.323 | |
| rs3916013 | 0.024 | 0.598 | |||
| REN | 9 | 0 | |||
| Arterial stiffness | |||||
| ACE | 3 | 0 | |||
| AGT | 13 | rs731824 | MAP | 0.022 | 0.397 |
| rs2478518 | FW | 0.024 | 0.688 | ||
| rs2478516 | FW | 0.037 | 0.217 | ||
| rs2478516 | RW | 0.046 | 0.663 | ||
| AGTR1 | 17 | rs1059502 | MAP | 0.025 | 0.023 |
| rs427832 | FW | 0.046 | 0.963 | ||
| CYP11B2 | 1 | rs2717594 | CF-PWV | 0.003 | 0.308 |
| NR3C2 | 26 | rs3910046 | CF-PWV | 0.009 | 0.383 |
| rs9307847 | CB-PWV | 0.011 | 0.741 | ||
| rs3910046 | CB-PWV | 0.014 | 0.409 | ||
| rs10519959 | CB-PWV | 0.018 | 0.175 | ||
| rs3846317 | RW | 0.021 | 0.649 | ||
| rs4835136 | CB-PWV | 0.027 | 0.268 | ||
| rs3846318 | RW | 0.042 | 0.293 | ||
| rs10519958 | RW | 0.049 | 0.529 | ||
| REN | 9 | rs16776 | FW | 0.012 | 0.115 |
| rs3911890 | FW | 0.022 | 0.207 | ||
*Includes all SNPs within 200 kb of start to 200 kb beyond end of gene, with genotype call rate >= 0.8; minor allele frequency >= 0.1; HWE p >= 0.001
CB-PWV = carotid-brachial pulse wave velocity; CF-PWV = carotid-femoral pulse wave velocity; DBP = diastolic blood pressure; FW = forward wave amplitude; MAP = mean arterial pressure; RW = reflected wave amplitude; SBP = systolic blood pressure