Table 2.

Association with nociceptor markers and putative subunit composition of ASIC current types

	Type 1	Type 2	Type 3
Association with markers (% of neurones)
TRPV1 current	76	79	81
AP with an inflection	47	100	100
IB4 binding*	14	60	41
Number of components in the activation curve†	1	≥ 2	2
Putative subunit composition‡	ASIC1a homomultimers	ASIC2-containing heteromers	ASIC1a- and ASIC3-containing heteromers§
Frequency (%)	59	15	26

The association between an ASIC current type and a given marker is indicated as the percentage of neurones positive for the given marker of the total number of neurones expressing this current type.

^*In control experiments (data not shown), the proportion of IB4-positive small-diameter neurones was 54% (n = 283). This factor was used to calculate from the data shown in Fig. 2D the fraction of IB4-binding neurones of the total population of neurones expressing a given ASIC current type.

^†From Fig. 3A, corresponding to the number of different populations of ASIC channels contributing to the current type.

^‡based on the biophysical and pharmacological analysis

^§concerning the main current component.