Figure 2. Stimulation of defecation by a ghrelin receptor agonist applied to conscious rats.
Bar graphs showing effects on fecal output of CP464709 (10 mg kg−1) or phosphate buffered saline (PBS; vehicle control) injected subcutaneously into conscious rats. A, the numbers of fecal pellets expelled more than doubled in the first four hours, but the output over the subsequent 18 h was similar in drug and vehicle-treated rats. B, cumulative fecal output at the ends of each of the first four hours, showing that output in CP464709 treated rats was greater than in control at all time points. All data are means ± s.e.m., n = 6 rats. *Significant difference from control, P < 0.05.