Figure 7. Lack of effect of the ghrelin receptor agonist on visceromotor reflexes.

In these experiments, an electromyograph (EMG) signal was recorded from the external oblique muscle when the colorectum was distended. A, visceromotor (pain) responses to ramp distensions of the colorectum. B, during infusion of CP464709 (10 mg kg⁻¹ h⁻¹, i.v.) phasic contractions were recorded by a pressure transducer connected to the intracolorectal balloon, but EMG responses to colorectal stimulation were unchanged.