Table 2.
Summary of the results of the patch-clamp electrophysiological recordings from DRG neurons isolated from sham or Nb-infected Nav1.8−/− and Nav1.8+/+ mice
| Nav1.8+/+ | Nav1.8−/− | |||||
|---|---|---|---|---|---|---|
| Sham | Nb infected | P value | Sham | Nb infected | P value | |
| n | 18 | 19 | 14 | 13 | ||
| Capacitance (pF) | 21.3 ± 2.4 | 21.9 ± 1.4 | 0.82 | 23.7 ± 3.3 | 22.4 ± 3.0 | 0.77 |
| Resting membrane potential (mV) | −57.6 ± 2.5 | −50.7 ± 1.9 | 0.41 | −54.6 ± 1.8 | −57.4 ± 2.1 | 0.22 |
| Rheobase (pA) | 180 ± 36 | 80 ± 24 | 0.03 | 165 ± 54 | 169 ± 39 | 0.95 |
| Normalized rheobase (pA pF−1) | 11.1 ± 2.5 | 3.7 ± 1.2 | 0.01 | 8.6 ± 3.5 | 9.9 ± 2.4 | 0.76 |
| Number of APs at 2× rheobase | 1.3 ± 0.3 | 3.2 ± 0.5 | 0.003 | 1.1 ± 0.1 | 1.0 ± 0 | 0.34 |
Data are expressed as mean ± s.e.m.; groups were compared by unpaired t tests.