Table 5.

Univariate and Multivariate Hazard Ratios and 95% Confidence Intervals for the Development of POAG in the Pooled OHTS and EGPS Control Groups

Baseline Variables	Model
	Univariate						Final Multivariate
	N	N events	HR	95%Low CI	95%Up CI	Pvalue	N	N events	HR	95%Low CI	95%Up CI	Pvalue
Age decade	1312	165	1.41	1.20	1.65	<.0001	1123	154	1.26	1.06	1.50	0.0072
Male gender	1312	165	1.23	0.91	1.67	0.1772
Mean IOP per mm Hg*	1312	165	1.10	1.03	1.17	0.0052	1123	154	1.09	1.03	1.17	0.0067
Mean CCT per 40 microns thinner	1128	156	2.16	1.81	2.59	<.0001	1123	154	2.04	1.70	2.45	<.0001
Mean Vertical C/D ratio per 0.1 larger	1311	165	1.21	1.12	1.32	<.0001	1123	154	1.19	1.09	1.31	0.0001
Mean PSD per 0.2 dB greater	1308	163	1.12	1.04	1.21	0.0019	1123	154	1.13	1.04	1.24	0.0065
History of heart disease	1312	165	1.62	1.00	2.61	0.0488
Mean deviation defect per 0.1 dB greater	1308	163	0.93	0.81	1.06	0.2799
History of high blood pressure	1312	165	1.14	0.83	1.56	0.4300
History of migraine	1312	165	0.90	0.51	1.58	0.7073
Current use systemic beta blockers	1309	165	0.99	0.49	2.01	0.9736
Current use systemic calcium channel blockers	1309	165	1.00	0.61	1.66	0.9876
Myopia ≥-1 D spherical equivalent	1312	165	0.89	0.64	1.25	0.5108

^*Eye-specific variables are the mean of right and left eyes for each participant

CCT Central corneal thickness

C/D Cup-to-disc ratio

CI Confidence interval

CPSD Corrected pattern standard deviation

D Diopter

dB Decibel

EGPS European Glaucoma Prevention Study

HR Hazard ratio

IOP Intraocular pressure

OHTS Ocular Hypertension Treatment Study

POAG Primary open angle glaucoma

PSD Pattern standard deviation