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. 2006 Jun 29;575(Pt 3):707–720. doi: 10.1113/jphysiol.2006.114439

Figure 2. NMDA triggers release of ATP from bovine RPE eyecup.

Figure 2

When added to the apical face of a bovine RPE eyecup preparation, NMDA triggered a concentration-dependent increase in bath levels of ATP. Both 100 and 300 μm NMDA elevated ATP levels more than threefold, giving an EC50 of 32 μm. Symbols represent the means ± s.e.m. from the number of eyes indicated, with concentrations normalized to the mean control levels for each experimental set. *P < 0.05 versus control value. The line is a fit of the exponential rise y = y0 + a(1 − e−bx) with y0 = 0.97, a = 2.3 and b = 0.028.