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. 2001 Apr 1;107(7):813–822. doi: 10.1172/JCI10947

Figure 5.

Figure 5

Premature death and cardiomegaly in MHC-ACS mice. (a) Wild-type (WT, n = 110) and transgenic (J3, n = 19; M13, n = 23; O7, n = 9) mice were followed for 130 days, and incidence of spontaneous death was recorded as a function of time. Differences among survival curves were compared using the log-rank test (AP < 0.05, BP < 0.01, CP < 0.0001). (b) At the time of spontaneous death or sacrifice, mice were weighed. Hearts were dissected, and atrial and vascular structures were removed before weighing. Heart-to-body weight ratios were determined in wild-type (solid bars) and transgenic (open bars for J3, M13, O7) mice older than 24 days at the time of death or sacrifice. For each transgenic mouse, an age- and sex-matched wild-type littermate was sacrificed and analyzed. Differences among groups were compared by two-way ANOVA (AP < 0.0001).