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EM of cardiac tissue from end-stage MHC-ACS O7 mice. Ventricular tissue from a 28-day-old transgenic mouse was fixed in formalin and thin sectioned for EM. ×15,000. Note complex structures composed of multiple layers of membrane in the cytoplasm of myocytes (a). In addition to these large multilamellar membrane aggregates, membranes often accumulated within the cytoplasm between organelles such as mitochondria (b) (arrow). Bar, 0.5 μm.
