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. 2007 Oct;18(10):4155–4167. doi: 10.1091/mbc.E07-02-0094

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© 2007 by The American Society for Cell Biology

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Figure 6. — Cdc42p relieves for3p autoinhibition to regulate its localization. (A) Single focal plane widefield fluorescent image of for3p-3GFP (left) and for3pDAD*-2GFP (right) in cdc42-1625 cells. Note that the DAD* mutation is sufficient to restore for3p localization to cell tips in cdc42-1625 mutant cells (arrowheads). (B) DIC images of for3-3GFP cdc42-1625 (left) and for3DAD*-2GFP cdc42-1625 (right) cells. The DAD* mutation improves the morphology of cdc42-1625 mutant cells. (C) Projection images of spinning disk confocal stacks of AlexaFluor 488-phalloidin–stained for3-3GFP cdc42-1625 (left) and for3DAD*-2GFP cdc42-1625 (right) cells. Arrowheads point at weak actin cables. Note that the DAD* mutation fails to restore wild-type actin cables in cdc42-1625 mutant cells.