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Proliferation of CD4+ T cells from wild-type, CD28–/–, and CD28/CTLA4–/– mice in the presence of syngeneic APCs. T cells from the indicated strains were stimulated in the presence of wild-type APCs with or without CTLA4-Ig or in the presence of B7-deficient APCs. Proliferation on day 3 is shown. Data are representative of five experiments.
