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. Author manuscript; available in PMC: 2007 Oct 1.
Published in final edited form as: Exp Neurol. 2007 Feb 14;205(1):92–100. doi: 10.1016/j.expneurol.2007.01.038

Fig 2.

Fig 2

Effect of A-type K+ channel blockers in phasically firing neurons (A–E) adult rat DRG neurons. A, The Kv4 K+ channel blocker heteropodatoxin (HPTx, 0.05 μM) increases firing in response to a current injection 600 ms long and 250 pA in intensity in a phasic neuron. B, Average increase in firing for experiment as shown in A in 6 neurons. C, The A-type K+ channel blocker 4-aminiopyridine (4AP, 50 μM, middle trace) increases firing in response to a current injection 600 ms long and 250 pA in intensity in a phasic neuron. Further increasing 4AP to 1 mM (lower trace), prolongs the action potentials and inhibits the increase in firing in response to lower concentrations of the drug, D, Average increase in firing for experiment as shown in C in 8 neurons. Dependence of firing on stimulus intensity for experiment in C and D before (Control, empty circles) and after HPTx (0.05 μM, filled circles), and 4AP (50 μM, filled squares, 1 mM, filled triangles).