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. Author manuscript; available in PMC: 2007 Oct 1.
Published in final edited form as: Exp Neurol. 2007 Feb 14;205(1):92–100. doi: 10.1016/j.expneurol.2007.01.038

Fig. 3.

Fig. 3

The neurokinin-mediated increase in firing in phasic DRG neurons requires activation of NK2 receptors. A, Substance P (0.5 μM, middle trace) increased firing from 3 APs (top trace, control) to 8 APs. Application of an NK2 antagonist, MEN10376 (0.5μM, bottom trace) reduced the increase in firing to near control rates. Firing in response to a current injection 600 ms long and 250 pA in intensity. B, Average increase in APs in response to SP and MEN10376 after SP in 4 neurons. C, A NK2-selective agonist, [βAla8]-neurokinin A (4–10) (NKA, 0.5 μM, bottom trace) increased firing from 1 APs (top trace, control) to 5 APs. Firing in response to a current injection 600 ms long and 250 pA in intensity. D, Average increase in APs in response to NKA in 6 neurons. E, Dependence of firing on stimulus intensity for experiment in D, before (Control, empty circles) and after NKA (0.5 μM, filled triangles).