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. 1998 Mar 31;95(7):4061–4065. doi: 10.1073/pnas.95.7.4061

Figure 2.

Figure 2

Effect of a high fat diet on obesity and symptoms of type II diabetes in obesity-resistant and obesity-prone strains of mice. Twenty mice from each of the three strains, A/J, B6, and KsJ, were obtained from The Jackson Laboratory at 3–4 weeks of age and placed on either a low fat diet or a high fat diet as described by Surwit (14). Body weight (A), plasma levels of glucose (B), and insulin (C) after an 8-hr fast were determined after 5 months. One-way ANOVA was performed for each parameter. Body weights, glucose, and insulin values of the low fat-fed animals were not different from each other (P > 0.05). For all three measures, the values for B6 H mice were greater than those for either the KsJ H or the A/J H mice (P < 0.001), whereas those for KsJ H and A/J H mice were not different from each other (P > 0.05). Other statistical comparisons between values for high fat and low fat fed animals are as follows: ∗, P < 0.001; #, P < 0.005; §, P < 0.02.