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. 1997 Mar 4;94(5):1657–1662. doi: 10.1073/pnas.94.5.1657

Figure 2.

Figure 2

Functional epitope of IL-4 determining the high-affinity binding of the receptor α chain. The 4-helix-bundle structure of IL-4 (17) is depicted as ribbons. The mutated residues are shown by space-filling models with their colors indicating the loss in binding free energy {ddG = 1.36 log(Kd[variant]/Kd[IL-4])} due to alanine or glutamine (E9, R53) substitution (see Table 2).

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