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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Brain Behav Immun. 2006 Dec 27;21(3):259–272. doi: 10.1016/j.bbi.2006.11.00

Figure 2. Glucocorticoid-increased immune cell response to CNS injury.

Figure 2

Rats were exposed to different amounts of GCs for three days, given a unilateral infusion of kainic acid in the CA3 region of the hippocampus and the abundance of different immune cells was quantified over 72 hours post kainic acid. This graph shows an increase in the abundance of different immune cells with increasing exposure to corticosterone. Rats in the basal group (white) were adrenalectomized and given a low-dose subcutaneous corticosterone pellet, which locks circulating corticosterone levels at a basal level. Rats in the intact group (gray) experienced a stress response from a sham adrenalectomy as well as a physiological stress response to kainic acid, but were otherwise unmanipulated. Rats in the high cort group (black) were injected daily with corticosterone in order to induce chronic high exposure. [From Dinkel et al. 2003 Blackwell publishing, with permission]