Table 2.
Phylogenetic/functional classifications and tissue distribution of mammalian MIPs
| Gene name | Phylogenetic AQP/GLP | Functional permeability | Tissue/cellular localization |
|---|---|---|---|
| AQP0 | AQP | Water | Lens of the eye |
| AQP1 | AQP | Water | Kidney (proximal tubule and thin descending limb of the loop of Henle), erythrocytes, capillary endothelium, choroid plexus, corneal epithelium, ear, lung, GI tract, skeletal muscle, heart muscle |
| AQP2 | AQP | Water | Kidney (principal cells of the collecting duct and connecting tubules; apical surface and subapical vesicles) |
| AQP3 | GLP | Urea and glycerol; water | Kidney (principal cells of the collecting duct and connecting tubules; basolateral surface), airways, lung, GI tract, brain, ear, urinary bladder, cornea, epidermis |
| AQP4 | AQP | Water | Kidney (collecting duct principal cells; basolateral), retina, ear, airways, lung, GI tract, fast-twitch skeletal muscle, glial cells at blood brain barrier, astrocytes |
| AQP5 | AQP | Water | Salivary gland, lacrimal gland, trachea, epithelia of nasopharynx and airways, alveolar type 1 cells, ear, eye, placenta, pancreas |
| AQP6 | AQP | Anions (NO−3 and Cl−; water | Kidney (intracellular vesicles in type A intercalated cells of the collecting duct) |
| AQP7 | GLP | Urea and glycerol; water, arsenite | Testis, sperm, kidney (proximal tubule), adipose tissue, skeletal muscle |
| AQP8 | AQP | Urea and NH3, water | Testis, sperm, GI tract, placenta, kidney (proximal tubule and collecting duct), airways, liver, salivary glands, glial and neuronal cells, pancreas |
| AQP9 | GLP | Urea and glycerol; water, arsenite | Liver, testis, sperm, spleen, brain, leukocytes, kidney, lung, brain (astrocytes and ependymal cells) |
| AQP10 | GLP | Urea and glycerol; water | Duodenum, jejunum |
| AQP11 | *SuperAQP | Unknown | Kidney (intracellular localization in proximal tubule), liver, testis, brain |
| AQP12 | *SuperAQP | Unknown | Pancreas (acinar cells) |