Table 4.
Functional enrichment analysis of the results of the differential network analysis
| Category | Term | Gene count | % Genes | p Value |
|---|---|---|---|---|
| GOTERM_CC_ALL | Extracellular region | 23 | 37.7% | 1.8 × 10−4 |
| UP_SEQ_FEATURE | Signal peptide | 22 | 36.1% | 5.4 × 10−4 |
| GOTERM_BP_ALL | Cell adhesion | 10 | 16.4% | 7.7 × 10−4 |
| UP_SEQ_FEATURE | Domain:EGF-like 1 | 5 | 8.2% | 8.7 × 10−4 |
| UP_SEQ_FEATURE | Glycosylation site:N-linked (GlcNAc...) | 21 | 34.4% | 0.0012 |
| UP_SEQ_FEATURE | Domain:EGF-like 3 | 4 | 6.6% | 0.0016 |
| SP_PIR_KEYWORDS | Cell adhesion | 7 | 11.5% | 0.0017 |
| SP_PIR_KEYWORDS | Collagen | 5 | 8.2% | 0.0018 |
| UP_SEQ_FEATURE | Domain:EGF-like 2 | 4 | 6.6% | 0.0060 |
| SMART_NAME | SM00181:EGF | 5 | 8.2% | 0.013 |
| SMART_NAME | SM00179:EGF_CA | 4 | 6.6% | 0.015 |
| SP_PIR_KEYWORDS | egf-like domain | 5 | 8.2% | 0.017 |
| INTERPRO_NAME | IPR000742:EGF-like, type 3 | 5 | 8.2% | 0.018 |
| INTERPRO_NAME | IPR006210:EGF | 5 | 8.2% | 0.021 |
We studied 61 differentially expressed and differentially connected genes in sector 3. Note the enrichment for EGF-related themes. Additional details including corrected p values can be found in Supplementary Material, Appendix C