Table 2.

RI residues selected for mutation

RI residue	Contacts in RNase A	Corresponding Ang residues
E287	K91	P88
K320	E86	L83
E401	R39	P38
C408	K66	—
Y434	L35, R39, K41, P42	L35, P38, K40, D41
D435	K41, V43	K40, I42
Y437	N67, Q69, N71, A109, E111, H119	—, —, N68, A106, E108, H114
S460	K7, Q11	H8, Q12

Contacts listed are those observed in the complex of pRI with RNase A (15). RI residue numbers are for hRI and are four higher than those of the corresponding amino acids in pRI (19, 20).