Table 3.
Kinetic parameters for the association of Ang with RI mutants
| RI | K1, μM | k2, s−1 | k2/K1, M−1·s−1 |
|---|---|---|---|
| wt | 0.29 | 80 | 2.8 × 108 |
| Y434A | 2.80 | 213 | 7.6 × 107 |
| D435A | 1.50 | 154 | 1.0 × 108 |
| Y437A | 0.34 | 69 | 2.0 × 108 |
| Des460 | 0.14 | 26 | 1.9 × 108 |
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