Fig. 1.

A scheme for the tail swing cycle of dynein coupled with its ATPase cycle. The indicated sequence of the ATPase cycle is based on previous kinetic studies on Tetrahymena outer-arm dynein (27–29). The nucleotides and mutations used to trap each intermediate state of the ATPase cycle are denoted in the second line. The two states of dynein tail position are indicated as D and D*. Here, D represents the motor domain in which the tail adopts the poststroke position, and D* represents the motor domain in which the tail adopts the prestroke position. The intermediate state D*-ADP given in parentheses is only tentatively assigned.