Figure 3 Sparc deficiency accelerates enterocyte movement along the crypt villus axis. (A) Cumulative frequency plot showing the distribution of bromodeoxyuridine (BrdU)‐labelled cells along the length of the crypt–villus axis 2 and 48 hours after exposure to BrdU. At 2 hours there is no difference in distribution between Sparc^−/−Apc^Min/+ and Sparc^+/+Apc^Min/+ mice (Kolmogorov–Smirnov, p  =  0.3). At 48 hours, enterocytes in the Sparc^−/−Apc^Min/+ mice have moved significantly further along the axis, indicated by a shift in the graph to the right (Kolmogorov–Smirnov, p  =  0.01). (B) The distribution at 48 hours; open bars, Sparc^−/−Apc^Min/+, closed bars, Sparc^+/+Apc^Min/+. For all data, a minimum of three mice were used of each genotype.