Table 2 Sensitivity, specificity, positive and negative predictive value of all studied markers in three “clinical situations”.
| Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) | |
|---|---|---|---|---|
| Crohn's disease (n = 913) vs. ulcerative colitis (n = 272) | ||||
| gASCA (⩾50 EU) | 56.4 | 90.4 | 95.2 | 38.2 |
| ALCA (⩾70 EU) | 17.7 | 93.0 | 89.5 | 25.2 |
| ACCA (⩾90 EU) | 20.7 | 84.9 | 82.2 | 24.2 |
| AMCA (⩾90 EU) | 28.1 | 82.4 | 84.3 | 25.5 |
| Omp (⩾25 EU) | 29.1 | 80.5 | 83.4 | 25.3 |
| pANCA* | 37.3 | 90.0 | 52.6 | 82.8 |
| IBD (n = 1225) vs healthy controls (n = 200) | ||||
| gASCA (⩾50 EU) | 44.8 | 99.0 | 99.6 | 22.7 |
| ALCA (⩾70 EU) | 14.9 | 98.5 | 98.4 | 15.9 |
| ACCA (⩾90 EU) | 19.3 | 85.5 | 89.1 | 14.7 |
| AMCA (⩾90 EU) | 25.9 | 92.0 | 95.2 | 16.8 |
| Omp (⩾25 EU) | 27.0 | 93.5 | 96.2 | 17.3 |
| pANCA | 17.2 | 97.5 | 97.7 | 16.2 |
| IBD (n = 1225) vs non‐IBD GI (n = 113) | ||||
| gASCA (⩾50 EU) | 44.8 | 98.2 | 99.6 | 14.1 |
| ALCA (⩾70 EU) | 14.9 | 99.1 | 99.5 | 9.7 |
| ACCA (⩾90 EU) | 19.3 | 84.1 | 92.9 | 8.8 |
| AMCA (⩾90 EU) | 25.9 | 92.9 | 97.5 | 10.4 |
| Omp (⩾25 EU) | 27.0 | 75.2 | 92.2 | 8.7 |
| pANCA | 17.2 | 93.8 | 96.8 | 9.4 |
ACCA, Anti‐chitobioside carbohydrate antibody; ALCA, anti‐laminaribioside carbohydrate antibody; AMCA, anti‐mannobioside carbohydrate antibody; EU, ELISA units; gASCA, anti‐Saccharomyces cerevisiae antibody; GI, gastrointestinal inflammation; IBD, inflammatory bowel disease; Omp, outer membrane porin; pANCA, perinuclear anti‐neutrophilic cytoplasmic antibody.
*pANCA accuracy to detect ulcerative colitis.