Table 4 Histology of duodenal mucosa in coeliac patients diagnosed in childhood and maintained on a normal diet until adulthood.
| Normal values (non‐coeliac controls) n = 13) | Total cohort (n = 61) | Latent (n = 13) | Silent (n = 48) | p Value latent vs silent | |
|---|---|---|---|---|---|
| Villous atrophy | 48/61 (79%) | 0/13 (0%) | 48/48 (100%) | ||
| PVA | 23/48 (48%) | ||||
| STVA | 25/48 (52%) | ||||
| Immunohistochemistry (mean (SD)) | |||||
| CD3+ IELs/100 enterocytes | 18 (7*) | 77 (26) | 51 (21) | 82 (21) | <0.001 |
| CD8+ IELs | 14 (7*) | 64 (25) | 43 (18) | 69 (22) | <0.001 |
| TCRαβ+ IELs | 14 (5*) | 51 (18) | 38 (20) | 55 (15) | <0.01 |
| TCRγδ+ IELs | 4 (2*) | 27 (14) | 24 (12) | 27 (15) | NS |
| TCRγδ+/CD3+ IELs (%) | 23 (9†) | 35 (12) | 41 (10) | 31 (13) | <0.01 |
*Significantly different from total cohort, latent and silent (p<0.001)
†Significantly different from total cohort (p<0.006), latent (p<0.001) and silent (p<0.03)
Latent, patients with no atrophy; silent, patients with villous atrophy.
IEL, intraepithelial lymphocyte; NS, non‐significant; PVA, partial villous atrophy; STVA, subtotal to total villous atrophy; TCR, T cell receptor.