Table 2 Results of sensitivity analyses.
No. of trials | Combined relative risks (95% CI) | |||||
---|---|---|---|---|---|---|
Initial hemostasis | Definitive hemostasis | Rebleeding | Need for surgery | Mortality | ||
Clips versus injections | ||||||
All trials | 8 | 1.01 (0.96 to 1.06) | 1.14 (1.00 to 1.30) | 0.49 (0.30 to 0.79) | 0.37 (0.15 to 0.90) | 1.45 (0.44 to 4.74) |
Study duration | ||||||
Shorter (< 4 weeks) | 4 | 0.99 (0.92 to 1.05) | 1.07 (0.87 to 1.32) | 0.59 (0.29 to 1.20) | 0.39 (0.12 to 1.27) | 1.64 (0.22 to 12.2) |
Longer ( 4 weeks) | 3 | 1.04 (0.97 to 1.11) | 1.23 (0.97 to 1.56) | 0.38 (0.18 to 0.80) | 0.34 (0.09 to 1.35) | 1.35 (0.31 to 5.89) |
Adjuvant proton pump inhibitors | ||||||
Yes | 2 | 1.00 (0.91 to 1.10) | 1.07 (0.94 to 1.21) | 0.59 (0.23 to 1.54) | 0.97 (0.06 to 14.8) | 2.97 (0.48 to 18.3) |
No | 6 | 1.01 (0.96 to 1.07) | 1.21 (0.98 to 1.49) | 0.46 (0.26 to 0.81) | 0.33 (0.12 to 0.86) | 0.68 (0.12 to 3.95) |
Quality | ||||||
High (> 3) | 3 | 0.99 (0.85 to 1.15) | 1.14 (0.75 to 1.74) | 0.62 (0.32 to 1.21) | 0.36 (0.09 to 1.46) | 0.51 (0.05 to 5.43) |
Low ( 3) | 5 | 1.03 (0.97 to 1.10) | 1.17 (1.06 to 1.29) | 0.39 (0.19 to 0.78) | 0.37 (0.11 to 1.20) | 2.18 (0.50 to 9.53) |
Clips with injection versus injections | ||||||
All trials | 7 | 1.00 (0.95 to 1.05) | 1.13 (1.03 to 1.23) | 0.47 (0.28 to 0.76) | 0.23 (0.08 to 0.70) | 1.23 (0.45 to 3.37) |
Study duration | ||||||
Shorter (< 4 weeks) | 4 | 0.97 (0.83 to 1.13) | 1.11 (0.96 to 1.28) | 0.54 (0.22 to 1.36) | 0.31 (0.07 to 1.32) | 0.81 (0.10 to 6.33) |
Longer ( 4 weeks) | 3 | 1.06 (0.97 to 1.16) | 1.20 (1.07 to 1.35) | 0.30 (0.11 to 0.78) | 0.09 (0.01 to 1.63) | 1.68 (0.23 to 12.5) |
Adjuvant Proton pump inhibitors | ||||||
Yes | 4 | 0.98 (0.82 to 1.18) | 1.15 (1.03 to 1.29) | 0.31 (0.16 to 0.63) | 0.28 (0.07 to 1.02) | 0.70 (0.19 to 2.64) |
No | 3 | 1.00 (0.93 to 1.07) | 1.09 (0.94 to 1.25) | 0.80 (0.39 to 1.64) | 0.16 (0.02 to 1.29) | 3.07 (0.05 to 18.7) |
Quality | ||||||
High (> 3) | 3 | 0.97 (0.87 to 1.09) | 1.08 (0.85 to 1.37) | 0.45 (0.22 to 0.93) | 0.27 (0.05 to 1.35) | 2.87 (0.59 to 14.1) |
Low ( 3) | 4 | 1.04 (0.96 to 1.13) | 1.15 (1.03 to 1.29) | 0.48 (0.24 to 0.94) | 0.21 (0.05 to 0.94) | 0.53 (0.12 to 2.39) |