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. 2007 Jun 12;56(10):1364–1373. doi: 10.1136/gut.2007.123976

Table 2 Results of sensitivity analyses.

No. of trials Combined relative risks (95% CI)
Initial hemostasis Definitive hemostasis Rebleeding Need for surgery Mortality
Clips versus injections
 All trials 8 1.01 (0.96 to 1.06) 1.14 (1.00 to 1.30) 0.49 (0.30 to 0.79) 0.37 (0.15 to 0.90) 1.45 (0.44 to 4.74)
 Study duration
  Shorter (< 4 weeks) 4 0.99 (0.92 to 1.05) 1.07 (0.87 to 1.32) 0.59 (0.29 to 1.20) 0.39 (0.12 to 1.27) 1.64 (0.22 to 12.2)
  Longer ( 4 weeks) 3 1.04 (0.97 to 1.11) 1.23 (0.97 to 1.56) 0.38 (0.18 to 0.80) 0.34 (0.09 to 1.35) 1.35 (0.31 to 5.89)
 Adjuvant proton pump inhibitors
  Yes 2 1.00 (0.91 to 1.10) 1.07 (0.94 to 1.21) 0.59 (0.23 to 1.54) 0.97 (0.06 to 14.8) 2.97 (0.48 to 18.3)
  No 6 1.01 (0.96 to 1.07) 1.21 (0.98 to 1.49) 0.46 (0.26 to 0.81) 0.33 (0.12 to 0.86) 0.68 (0.12 to 3.95)
 Quality
  High (> 3) 3 0.99 (0.85 to 1.15) 1.14 (0.75 to 1.74) 0.62 (0.32 to 1.21) 0.36 (0.09 to 1.46) 0.51 (0.05 to 5.43)
  Low ( 3) 5 1.03 (0.97 to 1.10) 1.17 (1.06 to 1.29) 0.39 (0.19 to 0.78) 0.37 (0.11 to 1.20) 2.18 (0.50 to 9.53)
Clips with injection versus injections
 All trials 7 1.00 (0.95 to 1.05) 1.13 (1.03 to 1.23) 0.47 (0.28 to 0.76) 0.23 (0.08 to 0.70) 1.23 (0.45 to 3.37)
 Study duration
  Shorter (< 4 weeks) 4 0.97 (0.83 to 1.13) 1.11 (0.96 to 1.28) 0.54 (0.22 to 1.36) 0.31 (0.07 to 1.32) 0.81 (0.10 to 6.33)
  Longer ( 4 weeks) 3 1.06 (0.97 to 1.16) 1.20 (1.07 to 1.35) 0.30 (0.11 to 0.78) 0.09 (0.01 to 1.63) 1.68 (0.23 to 12.5)
 Adjuvant Proton pump inhibitors
  Yes 4 0.98 (0.82 to 1.18) 1.15 (1.03 to 1.29) 0.31 (0.16 to 0.63) 0.28 (0.07 to 1.02) 0.70 (0.19 to 2.64)
  No 3 1.00 (0.93 to 1.07) 1.09 (0.94 to 1.25) 0.80 (0.39 to 1.64) 0.16 (0.02 to 1.29) 3.07 (0.05 to 18.7)
 Quality
  High (> 3) 3 0.97 (0.87 to 1.09) 1.08 (0.85 to 1.37) 0.45 (0.22 to 0.93) 0.27 (0.05 to 1.35) 2.87 (0.59 to 14.1)
  Low ( 3) 4 1.04 (0.96 to 1.13) 1.15 (1.03 to 1.29) 0.48 (0.24 to 0.94) 0.21 (0.05 to 0.94) 0.53 (0.12 to 2.39)