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. Author manuscript; available in PMC: 2007 Oct 4.
Published in final edited form as: Eur J Immunol. 2006 May;36(5):1187–1198. doi: 10.1002/eji.200535668

Figure 1.

Figure 1

CD4+ and DX5+ cells are the major producers of IL-13 following B7 blockade in T. muris-immunized mice. CTLA4-Ig or L6 (500 μg) was administered at days 0, 1 and 12 after oral inoculation of BALB/c mice (five mice/group) with T. muris (Tm) eggs. At day 21, CD4+, CD4−CD8+ and CD4−CD8−DX5+ cell populations were purified from pooled MLN cells using anti-CD4, anti-CD8 or anti-DX5 magnetic beads. IL-13, IL-4 and IFN-γ mRNA expression were detected by quantitative fluorogenic real-time PCR. Data were individually normalized to rRNA, and data for treatment groups are expressed relative to the uninfected controls. Similar results were obtained in two additional experiments.