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. Author manuscript; available in PMC: 2007 Oct 4.
Published in final edited form as: Eur J Immunol. 2006 May;36(5):1187–1198. doi: 10.1002/eji.200535668

Figure 4.

Figure 4

IL-13-mediated protection to T. muris after blockade of both B7 and IFN-γ is not dependent on IL-12. IL-12p40–/– and WT BALB/c mice (five mice/group) were administered CTLA4-Ig or L6 after T. muris (Tm) inoculation. Anti-IFN-γ mAb was used to block IFN-γ function in vivo. At day 21 post-immunization, (a) worm burdens were assessed by counting total numbers of adult worms in the gut, and (b) MLN cells were collected and IFN-γ-producing cells detected by ELISPOT. The means and SE from five individual mice are shown for each group. Similar results were obtained in two additional experiments. Asterisks indicate a statistically significant difference (**p<0.01) between the indicated groups.