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Representation of individual signals during time course of reaction. (a–c) Normalized integrals of imino proton signals: (a) red, core region signal U51/U67; (b) green, loop region signal G37/G38/G45; (c) blue, signal U81 that is part of helix P1 as a function of time with monoexponential fit (for signals U51/U67 and G37/G38/G45) and linear fit (for signal U81) (solid line); (d) stack plot of a series of 1H{15N}-NMR spectra as a function of time (imino proton subsection, 12.2–13.4 ppm).
