EC sensitization elicits a systemic Th-17. (A) IL-17A, IL-4, and IFN-γ secretion by OVA-stimulated splenocytes. (B) Serum IL-17A levels in EC versus i.p. sensitized mice. Columns and error bars represent mean± SEM (n = 4–7 per group). *, P < 0.05; **, P < 0.01; ***, P < 0.0001. N.D., not detectable; SAL, saline.