Fig. 2.

Enhanced mortality in PKCδ^−/− mice after LM infection despite increased levels of NF-IL6 and IL-6. Mice were infected with 2 × 10² cfu (A), 2 × 10³ cfu (B), or 2 × 10⁴ cfu (C) of LM, and mortality was measured for n = 7–10 mice per group (A), n = 11–12 mice per group (B), and n = 5 mice per group (C). (D) Quantitative RT-PCR of NF-IL6 and IL-6 in liver and spleens of WT and PKCδ^−/− mice at 2 days after LM infection with 2 × 10⁴ cfu (n = 5 per group). Data shown are means ± SEM (*, P < 0.05; ***, P < 0.0001). All results are representative of two independent experiments.