Vasculature associated with a murine carcinoma shown from an AP view. Left: Vessels segmented from brain with the same color-coding by anatomical grouping as in Figure 2. Center: The ventricular region of interest (grey) is shown together with the vessels. The vessel color coding in this and the next panel has changed to indicate relationship to the surface of the region of interest, with red vessels lying inside, gold vessels traversing, cyan vessels exiting, purple vessels entering, and blue vessels outside the region of interest. The distinction between entering and exiting vessels is enabled by the vessel tree structure. An arrow points to an obvious example of an abnormal traversing vessel (gold) with high curvature per unit distance (high tortuosity by SOAM). Right: The ventricular region is hidden; vessel color coding is the same as in the central panel except that a particular vessel of interest is colored white to make it easier to see.. An arrow points to a second example of an overtly abnormal vessel (colored white) with high-frequency, low-amplitude “wiggles” producing a high tortuosity value by SOAM.