Fig. 2.

PASK^−/− mice were protected from diet-induced glucose intolerance, insulin resistance, and obesity. (A–D) GTT and ITT with WT and PASK^−/− mice fed with either NCD (A and B) or HFD (C and D). Plasma glucose levels were determined before and at indicated times after i.p. glucose (A and C) or insulin (B and D) injection. (E and F) Growth curves of WT and PASK^−/− mice on NCD (E) or HFD (F) beginning at 12 weeks of age. All data represent the mean ± SEM for 12 male mice of each genotype. *, P < 0.05; **, P < 0.01.