Table 4.

Translation bypass of R338X and geneticin dosage

Geneticin dosage, mg/kg per day	Time point after 2 days of pretreatment, h	F9 antigen, ng/100 μl	F9 coagulant activity, %
0	2	1.71 ± 0.21 (2)	3.45 ± 0.21 (2)
7	2	2.28 ± 0.68 (2)	4.55 ± 0.64 (2)
14	2	5.79 ± 4.1 (4)	6.18 ± 2.48 (4)
28	2	8.75 ± 5.53 (19)	6.94 ± 3.11 (16)
28	9	27.28 ± 30.03 (23)*	8.03 ± 5.56 (16)
42	9	13.57 ± 13.72 (4)	4.98 ± 2.58 (4)

The time points range from 1.5 to 3 h with an average of 2 h. The numbers in parentheses indicate the number of mice.

*P = 0.011 Wilcoxon-Mann-Whitney test compared with F9 antigen 2 h after 28 mg/kg per day of treatment.