Fig. 5.

Agonist and antagonist dose/current response relationships of oocytes expressing GluR3 receptors. (A) There was no statistical difference between kainate EC₅₀ of WT GluR3, GFP-GluR3 and GluR3-GFP receptors. (B and C) GluR3-GFP has less sensitivity to glutamate alone, and to AMPA coapplied with 10 μM CTZ than the other GluR3 receptors. (D) Neither NBQX (left) nor CNQX (right) concentration/current relationships were altered by GFP tagging to WT GluR3. The action of CNQX and NBQX was evaluated on 30 μM Kai-currents. Currents were normalized to the maximum drug-elicited current for each oocyte (n = 3–9).